Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial.

ABSTRACT:

Background

Patients with type 2 diabetes (T2D) may experience frequent body weight changes over time. The prognostic impact of these weight changes (gains or losses) requires further study.

Aims

To study the associations between changes in body weight (intentional or unintentional) with subsequent outcomes.

Methods

The EXAMINE trial included 5380 patients with T2D and a recent acute coronary syndrome, who were randomized to alogliptin or placebo. Time-updated Cox models and mixed effects models were used to test the associations between changes in body weight and subsequent outcomes over a median follow-up of 1.6 (1.0-2.1) years.

Results

During the post-randomization follow-up period, 1044 patients (19.4%) experienced a weight loss ≥ 5% of baseline weight, 2677

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC8442423 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature