A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.
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ABSTRACT:
SUBMITTER: Yoon J
PROVIDER: S-EPMC8442857 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.
Yoon Jeehyun J Grinchuk Oleg V OV Kannan Srinivasaraghavan S Ang Melgious Jin Yan MJY Li Zhenglin Z Tay Emmy Xue Yun EXY Lok Ker Zhing KZ Lee Bernice Woon Li BWL Chuah You Heng YH Chia Kimberly K Tirado Magallanes Roberto R Liu Chenfei C Zhao Haonan H Hor Jin Hui JH Lim Jhin Jieh JJ Benoukraf Touati T Toh Tan Boon TB Chow Edward Kai-Hua EK Kovalik Jean-Paul JP Ching Jianhong J Ng Shi-Yan SY Koh Ming Joo MJ Liu Xiaogang X Verma Chandra Shekhar CS Ong Derrick Sek Tong DST
Science advances 20210903 36
Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use a chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole (SN) with anti-GSC properties, we find that SN disrupts biotin distribution to the carboxylases and histones. Transcriptomic and metabolomic analyses of SN-treated GSCs reveal metabolic alterations that are characteristic of biotin-deficient cells, including intracellular cholesterol depletion, impairm ...[more]
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