Zona incerta subpopulations differentially encode and modulate anxiety.
Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC8442884 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Zona incerta subpopulations differentially encode and modulate anxiety.
Li Zhuoliang Z Rizzi Giorgio G Tan Kelly R KR
Science advances 20210910 37
Despite recent clinical observations linking the zona incerta (ZI) to anxiety, little is known about whether and how the ZI processes anxiety. Here, we subject mice to anxious experiences and observe an increase in ZI c-fos–labeled neurons and single-cell calcium activity as well as an efficient effect of ZI infusion of diazepam, a classical anxiolytic drug. We further identify that somatostatin (SOM)–, calretinin (CR)–, and vesicular glutamate transporter-2 (Vglut2)–expressing cells display uni ...[more]
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