Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles.
Ontology highlight
ABSTRACT:
SUBMITTER: Staufer O
PROVIDER: S-EPMC8442894 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles.
Staufer Oskar O Dietrich Franziska F Rimal Rahul R Schröter Martin M Fabritz Sebastian S Boehm Heike H Singh Smriti S Möller Martin M Platzman Ilia I Spatz Joachim Pius JP
Science advances 20210903 36
Extracellular vesicles (EVs) are fundamental for intercellular communication and influence nearly every process in cell physiology. However, because of their intricate molecular complexity, quantitative knowledge on their signaling mechanisms is missing, particularly impeding their therapeutic application. We used a complementary and quantitative engineering approach based on sequential synthetic bottom-up assembly of fully functional EVs with precisely controlled lipid, protein, and RNA composi ...[more]
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