Tolerability and Efficacy of Long-Term Medical Therapy in Primary Aldosteronism.

ABSTRACT:

Introduction

Patients with primary aldosteronism (PA) have increased cardiovascular risk, and there are concerns about the efficacy of medical therapy.

Objective

We aimed to assess long-term tolerability and efficacy of medical therapy in PA patients.

Methods

We conducted a retrospective study on 201 PA patients treated with medical therapy (spironolactone, eplerenone, or amiloride) from 2000 to 2020 at 2 tertiary centers. Clinical and biochemical control and side effects were assessed.

Results

Among 155 patients on long-term medications, 57.4% achieved blood pressure (BP) <140/90 mmHg, 90.1% achieved normokalemia (48.0% potassium ≥4.3 mmol/L), and 63.2% achieved renin >1 ng/mL/h. Concordance of biochemical control using potassium and renin levels was 49.1%. Si

SUBMITTER: Tang F 

PROVIDER: S-EPMC8442943 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature