Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants.

ABSTRACT: Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new therapeutics. The surface spike protein, which plays a central role in virus infection, is currently the target for vaccines and neutralizing treatments. The emergence of novel variants with multiple mutations in the spike protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein with angiotensin-converting enzyme 2 (ACE2). To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody (mAb) therapies, the binding activities of the original spike protein receptor binding domain (RBD) sequence and the reported spike

SUBMITTER: Raghu D 

PROVIDER: S-EPMC8443317 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature