Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC8443782 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Yu Li L Zhang Yangyang Y Zhao Xixi X Wan Haitong H He Yu Y Jin Weifeng W
Frontiers in pharmacology 20210902
Guhong injection (GHI) is a drug for ischemic stroke created by combining safflower, a traditional Chinese medicine, and aceglutamide, a Western medicine. In this study, we investigated the curative effect of GHI on cerebral ischemia-reperfusion (I/R) injury via the PKC/HIF-1α pathway in rats. Adult male Sprague Dawley rats were randomly divided into seven groups: sham-operated, middle cerebral artery occlusion (MCAO), GHI, nimodipine injection (NMDP), MCAO + LY317615 (PKC inhibitor), GHI + LY31 ...[more]