Ontology highlight
ABSTRACT:
SUBMITTER: Majumdar S
PROVIDER: S-EPMC8444552 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Majumdar Soumabrata S Mezari Brahim B Zhang Huiyi H van Aart Jeroen J van Benthem Rolf A T M RATM Heuts Johan P A JPA Sijbesma Rint P RP
Macromolecules 20210817 17
Bond exchange via neighboring group-assisted reactions in dynamic covalent networks results in efficient mechanical relaxation. In Nature, the high reactivity of RNA toward nucleophilic substitution is largely attributed to the formation of a cyclic phosphate ester intermediate via neighboring group participation. We took inspiration from RNA to develop a dynamic covalent network based on β-hydroxyl-mediated transesterifications of hydroxyethyl phosphate triesters. A simple one-step synthetic st ...[more]