Review of the Current Trends in Clinical Trials Involving Induced Pluripotent Stem Cells.

ABSTRACT: In 2006, the induced pluripotent stem cell (iPSC) was presented to the world, paving the way for the development of a magnitude of novel therapeutic alternatives, addressing a diverse range of diseases. However, despite the immense cell therapy potential, relatively few clinical trials evaluating iPSC-technology have actually translated into interventional, clinically applied treatment regimens. Herein, our aim was to determine trends in globally conducted clinical trials involving iPSCs. Data were derived both from well-known registries recording clinical trials from across the globe, and databases from individual countries. Comparisons were firstly drawn between observational and interventional studies before the latter was further analyzed in terms of therapeutic and nontherapeutic tria

SUBMITTER: Kim JY 

PROVIDER: S-EPMC8445612 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature