Dataset Information

Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.

ABSTRACT: We measured plasma and cerebrospinal fluid (CSF) metabolite concentrations in a 5-day porcine sepsis model of fecal peritonitis. The objectives were: (i) to verify whether the expected pathways that had emerged in previous studies pertain only to the early inflammatory response or persist for the subsequent days; (ii) to identify metabolic derangements that arise later; (iii) to verify whether CSF metabolite concentrations were altered and if these alterations were similar to those in the blood or delayed. We observed an early response to inflammation and cytokine storms with alterations in lipid and glucose metabolism. The arginine/asymmetric dimethylarginine (ADMA) and phenylalanine/tyrosine balances changed 24 h after resuscitation in plasma, and later in CSF. There was a rise in ammonia concentration, with altered concentrations of metabolites in the urea cycle. Whether persistent derangement of these pathways have a role not only on short-term outcomes but also on longer-term comorbidities, such as septic encephalopathy, should be addressed in further studies.

SUBMITTER: Ferrario M

PROVIDER: S-EPMC8445921 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.

Ferrario Manuela M Pastorelli Roberta R Brunelli Laura L Liu Shengchen S Zanella do Amaral Campos Pedro Paulo PP Casoni Daniela D Z'Graggen Werner J WJ Jakob Stephan M SM

Scientific reports 20210916 1

We measured plasma and cerebrospinal fluid (CSF) metabolite concentrations in a 5-day porcine sepsis model of fecal peritonitis. The objectives were: (i) to verify whether the expected pathways that had emerged in previous studies pertain only to the early inflammatory response or persist for the subsequent days; (ii) to identify metabolic derangements that arise later; (iii) to verify whether CSF metabolite concentrations were altered and if these alterations were similar to those in the blood ...[more]

PMID: 34531431

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Dataset Information

Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.

Publications

Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.

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