Association between long non-coding RNA (lncRNA) GAS5 polymorphism rs145204276 and cancer risk.

ABSTRACT:

Objective

The long non-coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) plays an important role in various tumors, and an increasing number of studies have explored the association of the GAS5 rs145204276 polymorphism with cancer risk with inconclusive results.

Methods

PubMed, Medline, EMBASE, Cochrane databases, and Web of Science were searched, and nine studies involving 6107 cases and 7909 controls were deemed eligible. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the relationship between rs145204276 and cancer risk in six genetic models.

Results

The pooled results suggest that the variant allele del was not associated with overall cancer risk. However, the subgroup analysis showed that allele del was

SUBMITTER: Zhao S 

PROVIDER: S-EPMC8447101 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature