Adding saliva testing to oropharyngeal and deep nasal swab testing increases PCR detection of SARS-CoV-2 in primary care and children.

ABSTRACT:

Objective

To compare the concordance and acceptability of saliva testing with standard-of-care oropharyngeal and bilateral deep nasal swab testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in children and in general practice.

Design

Prospective multicentre diagnostic validation study.

Setting

Royal Children's Hospital, and two general practices (cohealth, West Melbourne; Cirqit Health, Altona North) in Melbourne, July-October 2020.

Participants

1050 people who provided paired saliva and oropharyngeal-nasal swabs for SARS-CoV-2 testing.

Main outcome measures

Numbers of cases in which SARS-CoV-2 was detected in either specimen type by real-time polymerase chain reaction; concordance of results for paired specimens; positive percent a

SUBMITTER: Oliver J 

PROVIDER: S-EPMC8447377 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature