Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC8449777 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Wang Lingfang L Du Xing X Li Qiqi Q Wu Wangjun W Pan Zengxiang Z Li Qifa Q
Cell death discovery 20210918 1
Transforming growth factor-β1 (TGF-β1) is essential for ovarian function and female fertility in mammals. Herein, we identified three completely linked variants, including two known variants referred to as c.1583A > G and c.1587A > G and the novel variant c.2074A > C in the porcine TGF-β1 3'-UTR. An important role of these variants in Yorkshire sow fertility was revealed. Variants c.1583A > G and c.1587A > G were located at the miRNA response element (MRE) of miR-2337 and affected miR-2337 regul ...[more]