Sexual dimorphism in vascular ATP-sensitive K⁺ channel function supporting interstitial PO2 via convective and/or diffusive O₂ transport.

ABSTRACT:

Key points

Inhibition of pancreatic ATP-sensitive K⁺ (K_ATP ) channels is the intended effect of oral sulphonylureas to increase insulin release in diabetes. However, pertinent to off-target effects of sulphonylurea medication, sex differences in cardiac K_ATP channel function exist, whereas potential sex differences in vascular K_ATP channel function remain unknown. In the present study, we assessed vascular K_ATP channel function (topical glibenclamide superfused onto fast-twitch oxidative skeletal muscle) supporting blood flow and interstitial O₂ delivery-utilization matching ( PO2 is) during twitch contractions in male, female during pro-oestrus and ovariectomized female (F+OVX) rats. Glibenclamide decreased blood fl

SUBMITTER: Colburn TD 

PROVIDER: S-EPMC8451062 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature