Dataset Information

Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial.

ABSTRACT:

Background

Intraoperative EEG suppression duration has been associated with postoperative delirium and mortality. In a clinical trial testing anaesthesia titration to avoid EEG suppression, the intervention did not decrease the incidence of postoperative delirium, but was associated with reduced 30-day mortality. The present study evaluated whether the EEG-guided anaesthesia intervention was also associated with reduced 1-yr mortality.

Methods

This manuscript reports 1 yr follow-up of subjects from a single-centre RCT, including a post hoc secondary outcome (1-yr mortality) in addition to pre-specified secondary outcomes. The trial included subjects aged 60 yr or older undergoing surgery with general anaesthesia between January 2015 and May 2018. Patients were randomised to receive EEG-guided anaesthesia or usual care. The previously reported primary outcome was postoperative delirium. The outcome of the current study was all-cause 1-yr mortality.

Results

Of the 1232 subjects enrolled, 614 subjects were randomised to EEG-guided anaesthesia and 618 subjects to usual care. One-year mortality was 57/591 (9.6%) in the guided group and 62/601 (10.3%) in the usual-care group. No significant difference in mortality was observed (adjusted absolute risk difference, -0.7%; 99.5% confidence interval, -5.8% to 4.3%; P=0.68).

Conclusions

An EEG-guided anaesthesia intervention aiming to decrease duration of EEG suppression during surgery did not significantly decrease 1-yr mortality. These findings, in the context of other studies, do not provide supportive evidence for EEG-guided anaesthesia to prevent intermediate term postoperative death.

Clinical trial registration

NCT02241655.

SUBMITTER: Fritz BA

PROVIDER: S-EPMC8451237 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial.

Fritz Bradley A BA King Christopher R CR Mickle Angela M AM Wildes Troy S TS Budelier Thaddeus P TP Oberhaus Jordan J Park Daniel D Maybrier Hannah R HR Ben Abdallah Arbi A Kronzer Alex A McKinnon Sherry L SL Torres Brian A BA Graetz Thomas J TJ Emmert Daniel A DA Palanca Ben J BJ Stevens Tracey W TW Stark Susan L SL Lenze Eric J EJ Avidan Michael S MS

British journal of anaesthesia 20210707 3

<h4>Background</h4>Intraoperative EEG suppression duration has been associated with postoperative delirium and mortality. In a clinical trial testing anaesthesia titration to avoid EEG suppression, the intervention did not decrease the incidence of postoperative delirium, but was associated with reduced 30-day mortality. The present study evaluated whether the EEG-guided anaesthesia intervention was also associated with reduced 1-yr mortality.<h4>Methods</h4>This manuscript reports 1 yr follow-u ...[more]

PMID: 34243940

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Dataset Information

Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial.

Background

Methods

Results

Conclusions

Clinical trial registration

Publications

Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial.

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