Effects and Safety of a Novel Oral Potassium-Lowering Drug-Sodium Zirconium Cyclosilicate for the Treatment of Hyperkalemia: a Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Oral sodium zirconium cyclosilicate (SZC) is a novel potassium binder capable of achieving a rapid reduction of serum potassium (sK⁺) and maintaining a long-term normokalemia. We undertook a meta-analysis to summarize and evaluate the effects surrounding SZC in patients with hyperkalemia.

Method

We searched data sources from MEDLINE (from 1950 to Sep 2020), EMBASE (from 1970 to Sep 2020), and the Cochrane Library database (from 1950 to Sep 2020) for eligible studies. All randomized controlled trials (RCTs) regarding comparison of therapeutic effects of SZC in hyperkalemia participants were included.

Results

Seven studies, including 1697 patients with hyperkalemia, were analyzed. SZC significantly reduced mean sK⁺ (-0.42 mmol/L; 95% CI:

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8452568 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature