Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency.

ABSTRACT:

Purpose

Immune dysregulation complications cause significant morbidity and mortality in common variable immunodeficiency (CVID), but the underlying pathophysiology is poorly understood. While CVID is primarily considered a B-cell defect, resulting in the characteristic hypogammaglobulinemia, T-cells may also contribute to immune dysregulation complications. Here, we aim to further characterize T-cell activation and regulation in CVID with immune dysregulation (CVIDid).

Methods

Flow cytometry was performed to investigate T-cell differentiation, activation and intracellular cytokine production, negative regulators of immune activation, regulatory T-cells (Treg), and homing markers in 12 healthy controls, 12 CVID patients with infections only (CVIDio), and 20 CVIDid patients.

SUBMITTER: Berbers RM 

PROVIDER: S-EPMC8452589 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature