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Predicting Layoff among Fragile Families.

ABSTRACT: The loss of a job is the loss of a major social and economic role and is associated with long-term negative economic and psychological consequences for workers and families. Modeling the causal effects of a social process like layoff with observational data depends crucially on the degree to which the model accounts for the characteristics that predict loss. We report analyses predicting layoff in the Fragile Families data as part of the Fragile Families Challenge. Our model, grounded in empirical social science research on layoff, did not perform substantially worse than the best-performing model using data science techniques. This result is not fully unforeseen, given that layoff functions as a relatively exogenous shock. Future work using the results of the Challenge should attend to whether small improvements in prediction models, like those we observe across models of layoff, nevertheless significantly increase the validity of subsequent models for causal inference.

SUBMITTER: Ahearn CE

PROVIDER: S-EPMC8455106 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Penetrance of FMR1 premutation associated pathologies in fragile X syndrome families.

Project description:Within the past few years, there has been a significant change in identifying and characterizing the FMR1 premutation associated phenotypes. The premutation has been associated with elevated FMR1 mRNA levels and slight to moderate reductions in FMRP levels. Furthermore, it has been established that approximately 20% of female premutation carriers present primary ovarian insufficiency (POI) and that fragile X-associated tremor/ataxia syndrome (FXTAS) occurs in one-third of all male premutation carriers older than 50 years. Besides POI and FXTAS, new disorders have recently been described among individuals (especially females) with the FMR1 premutation. Those pathologies include thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. However there are few reports related to FXTAS penetrance among female premutation carriers or regarding these disorders recently associated to the FMR1 premutation. Therefore, we have evaluated 398 fragile X syndrome (FXS) families in an attempt to provide an estimation of the premutation associated phenotypes penetrance. Our results show that signs of FXTAS are detected in 16.5% of female premutation carriers and in 45.5% of premutated males older than 50 years. Furthermore, among females with the FMR1 premutation, penetrance of POI, thyroid disease and chronic muscle pain is 18.6, 15.9 and 24.4%, respectively. The knowledge of this data might be useful for accurate genetic counselling as well as for a better characterization of the clinical phenotypes of FMR1 premutation carriers.

| S-EPMC2986640 | biostudies-literature

Diagnosis of fragile X syndrome: a qualitative study of African American families.

Project description:Fragile X syndrome (FXS) is an inherited genetic condition with critical consequences to the proband and family members at all levels in the generations. Although evidence demonstrates that the rates of diagnosis for FXS are the same in all racial groups, age of diagnosis in African American children has been reported to occur later than in Caucasian children. Additionally, African American families are seriously under-represented in existing FXS research studies. As such, it is important to understand the possible disparities in the underlying factors to receiving a diagnosis in African American families with FXS. Herein, a qualitative approach was adopted to describe the overall FXS diagnosis experiences (pre-diagnosis, diagnosis, and post-diagnosis stages) of a convenience sample of 10 African American mothers. We identified three major findings among our participants: (1) FXS testing is not ordered immediately once a parent expresses concerns of developmental delays to the pediatricians, (2) the diagnosis is sometimes delivered in an insensitive manner with information often being outdated and unbalanced towards negative aspects, (3) communication issues among family members exists once the diagnosis is discovered. Although these qualitative data may not be representative of the whole group, these findings have significant implications for genetic counseling and our understanding in providing support and advocacy for African American families with FXS.

| S-EPMC3508319 | biostudies-literature

Contributions of the Fragile Families and Child Wellbeing Study to Child Development

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Deprivation and psychopathology in the Fragile Families Study: A 15-year longitudinal investigation.

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Low Density Genotyping from the Fragile Families & Child Wellbeing Study

Project description:Low Density Genotyping from the Fragile Families & Child Wellbeing Study

| PRJNA727631 | ENA

Low Density Genotyping from the Fragile Families & Child Wellbeing Study

Project description:Low Density Genotyping from the Fragile Families & Child Wellbeing Study

| PRJNA727632 | ENA

Voice of People with Fragile X Syndrome and Their Families: Reports from a Survey on Treatment Priorities.

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| S-EPMC6406416 | biostudies-literature

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| S-EPMC7140891 | biostudies-literature

Predicting specificity-determining residues in two large eukaryotic transcription factor families.

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