Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal.

ABSTRACT:

Background

Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo and the giant panda provide an ideal system to bridge this gap.

Results

Here, integrating metabolomic and metagenomic approaches, and in vitro culture experiment, we identified 97 flavonoids in bamboo and most of them have not been identified previously; the utilization of more than 70% flavonoid monomers was attributed to gut microbiota; the variation of flavonoid in bamboo leaves and shoots shaped the seasonal microbial fluctuation. The greater the flavonoid content in the diet was, the

SUBMITTER: Wang L 

PROVIDER: S-EPMC8456708 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature