Chemoselective γ-Oxidation of β,γ-Unsaturated Amides with TEMPO.
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ABSTRACT: A chemoselective and robust protocol for the γ-oxidation of β,γ-unsaturated amides is reported. In this method, electrophilic amide activation, in a rare application to unsaturated amides, enables a regioselective reaction with TEMPO resulting in the title products. Radical cyclisation reactions and oxidation of the synthesised products highlight the synthetic utility of the products obtained.
SUBMITTER: Heindl S
PROVIDER: S-EPMC8456850 | biostudies-literature |
REPOSITORIES: biostudies-literature
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