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ABSTRACT:
SUBMITTER: Morgen M
PROVIDER: S-EPMC8456977 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Morgen Michael M Fabrowski Piotr P Amtmann Eberhard E Gunkel Nikolas N Miller Aubry K AK
Chemistry (Weinheim an der Bergstrasse, Germany) 20210713 47
The gold(I)-dithiocarbamate (dtc) complex [Au(N,N-diethyl)dtc]<sub>2</sub> was identified as the active cytotoxic agent in the combination treatment of sodium aurothiomalate and disulfiram on a panel of cancer cell lines. In addition to demonstrating pronounced differential cytotoxicity to these cell lines, the gold complex showed no cross-resistance in therapy-surviving cancer cells. In the course of a medicinal chemistry campaign on this class of poorly soluble gold(I)-dtc complexes, >35 deriv ...[more]