Fetal-placental blood flow and neurodevelopment in childhood: population-based neuroimaging study.

ABSTRACT:

Objective

Antenatal Doppler measurements of the fetal umbilical and cerebral circulations can predict perinatal complications; however, it is unclear if subtle variations in antenatal Doppler measurements are associated with long-term neurodevelopmental outcome. In this study, we examined whether antenatal Doppler measurements of the fetal-placental circulation are associated with cognitive and motor abilities and brain morphology in childhood.

Methods

To evaluate differences in long-term sequelae across the continuum of the umbilical and cerebral artery circulations in the general population, we utilized a population-based longitudinal cohort study approach. In women from the Generation R study, we measured second- and third-trimester umbilical artery pulsatility index (UA-

SUBMITTER: Sammallahti S 

PROVIDER: S-EPMC8457176 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature