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A study of elective genome sequencing and pharmacogenetic testing in an unselected population.

ABSTRACT:

Background

Genome sequencing (GS) of individuals without a medical indication, known as elective GS, is now available at a number of centers around the United States. Here we report the results of elective GS and pharmacogenetic panel testing in 52 individuals at a private genomics clinic in Alabama.

Methods

Individuals seeking elective genomic testing and pharmacogenetic testing were recruited through a private genomics clinic in Huntsville, AL. Individuals underwent clinical genome sequencing with a separate pharmacogenetic testing panel.

Results

Six participants (11.5%) had pathogenic or likely pathogenic variants that may explain one or more aspects of their medical history. Ten participants (19%) had variants that altered the risk of disease in the future, including two individuals with clonal hematopoiesis of indeterminate potential. Forty-four participants (85%) were carriers of a recessive or X-linked disorder. All individuals with pharmacogenetic testing had variants that affected current and/or future medications.

Conclusion

Our study highlights the importance of collecting detailed phenotype information to interpret results in elective GS.

SUBMITTER: Cochran M

PROVIDER: S-EPMC8457704 | biostudies-literature |

REPOSITORIES: biostudies-literature

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