Ontology highlight
ABSTRACT:
SUBMITTER: Huttinger ZM
PROVIDER: S-EPMC8458277 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Huttinger Zachary M ZM Haynes Laura M LM Yee Andrew A Kretz Colin A CA Holding Matthew L ML Siemieniak David R DR Lawrence Daniel A DA Ginsburg David D
Scientific reports 20210922 1
The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants render PAI-1 non-functional through misfolding, leading to its turnover as a protease substrate, or to a more rapid transition to the latent/inactive state. Deep mutational scanning was performed to evaluate the impact of amino acid sequence va ...[more]