Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties.

ABSTRACT: Based on the phase separation phenomenon in micro-droplets, polymer-lipid Janus particles were prepared on a microfluidic flow focusing chip. Phase separation of droplets was caused by solvent volatilization and Janus morphology was formed under the action of interfacial tension. Because phase change from solid to liquid of the lipid hemisphere could be triggered by physiological temperature, the lipid hemisphere could be used for rapid release of drugs. While the polymer we selected was pH sensitive that the polymer hemisphere could degrade under acidic conditions, making it possible to release drugs in a specific pH environment, such as tumor tissues. Janus particles with different structures were obtained by changing the experimental conditions. To widen the application range of the par

SUBMITTER: Feng ZY 

PROVIDER: S-EPMC8458873 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature