Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism.

ABSTRACT: The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached p

SUBMITTER: Pulgar E 

PROVIDER: S-EPMC8460252 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature