An Ancient Adenosine Receptor Gains Olfactory Function in Bony Vertebrates.

ABSTRACT: Nucleotides are an important class of odorants for aquatic vertebrates such as frogs and fishes, but also have manifold signaling roles in other cellular processes. Recently, an adenosine receptor believed to belong to the adora2 clade has been identified as an olfactory receptor in zebrafish. Here, we set out to elucidate the evolutionary history of both this gene and its olfactory function. We have performed a thorough phylogenetic study in vertebrates, chordates and their sister group, ambulacraria, and show that the origin of the zebrafish olfactory receptor gene can be traced back to the most recent common ancestor of all three groups as a segregate sister clade (adorb) to the adora gene family. Eel, carp, and clawed frog all express adorb in a sparse and distributed pattern within th

SUBMITTER: Kowatschew D 

PROVIDER: S-EPMC8462279 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature