Effect of 1-MHz ultrasound on the proinflammatory interleukin-6 secretion in human keratinocytes.

ABSTRACT: Keratinocytes, the main cell type of the skin, are one of the most exposed cells to environmental factors, providing a first defence barrier for the host and actively participating in immune response. In fact, keratinocytes express pattern recognition receptors that interact with pathogen associated molecular patterns and damage associated molecular patterns, leading to the production of cytokines and chemokines, including interleukin (IL)-6. Herein, we investigated whether mechanical energy transported by low intensity ultrasound (US) could generate a mechanical stress able to induce the release of inflammatory cytokine such IL-6 in the human keratinocyte cell line, HaCaT. The extensive clinical application of US in both diagnosis and therapy suggests the need to better understand the rel

SUBMITTER: Giantulli S 

PROVIDER: S-EPMC8463532 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature