Ontology highlight
ABSTRACT:
SUBMITTER: Osuna de la Pena D
PROVIDER: S-EPMC8463670 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Osuna de la Peña David D Trabulo Sara Maria David SMD Collin Estelle E Liu Ying Y Sharma Shreya S Tatari Marianthi M Behrens Diana D Erkan Mert M Lawlor Rita T RT Scarpa Aldo A Heeschen Christopher C Mata Alvaro A Loessner Daniela D
Nature communications 20210924 1
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These may especially benefit the management of pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high cancer stem cell (CSC) content and high density of stromal cells and extracellular matrix (ECM). To date, these fea ...[more]