The effects of housing density on mouse thermal physiology depend on sex and ambient temperature.

ABSTRACT:

Objective

To improve understanding of mouse energy homeostasis and its applicability to humans, we quantitated the effects of housing density on mouse thermal physiology in both sexes.

Methods

Littermate wild type and Brs3-null mice were single- or group- (three per cage) housed and studied by indirect calorimetry with continuous measurement of core body temperature, energy expenditure, physical activity, and food intake.

Results

At 23 °C, below thermoneutrality, single-housed males had a lower body temperature and unchanged metabolic rate compared to group-housed controls. In contrast, single-housed females maintained a similar body temperature to group-housed controls by increasing their metabolic rate. With decreasing ambient temperature below 27 °C, only group-hou

SUBMITTER: Skop V 

PROVIDER: S-EPMC8463779 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature