The heterogeneity among subgroups of haplogroup J influencing Alzheimer's disease risk.

ABSTRACT:

Introduction

The impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.

Objectives

The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level.

Methods

In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements.

Results

The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs

SUBMITTER: Liu H 

PROVIDER: S-EPMC8463963 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature