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Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings.

ABSTRACT: Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents.

SUBMITTER: Aksenov AV

PROVIDER: S-EPMC8464891 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings.

Aksenov Alexander V AV Kirilov Nikita K NK Aksenov Nicolai A NA Aksenov Dmitrii A DA Sorokina Elena A EA Lower Carolyn C Rubin Michael M

Molecules (Basel, Switzerland) 20210920 18

Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-<i>a</i>]quinolines with 1,3,4-oxadiazole substituents. ...[more]

PMID: 34577163

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