The pH-Dependent Controlled Release of Encapsulated Vitamin B₁ from Liposomal Nanocarrier.

ABSTRACT: In this work, we firstly presented a simple encapsulation method to prepare thiamine hydrochloride (vitamin B₁)-loaded asolectin-based liposomes with average hydrodynamic diameter of ca. 225 and 245 nm under physiological and acidic conditions, respectively. In addition to the optimization of the sonication and magnetic stirring times used for size regulation, the effect of the concentrations of both asolectin carrier and initial vitamin B₁ on the entrapment efficiency (EE %) was also investigated. Thermoanalytical measurements clearly demonstrated that after the successful encapsulation, only weak interactions were discovered between the carriers and the drug molecules. Moreover, the dissolution profiles under physiological (pH = 7.40) and gastric conditions (pH = 1.

SUBMITTER: Juhasz A 

PROVIDER: S-EPMC8466024 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature