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Musings from the Tribbles Research and Innovation Network.

ABSTRACT: This commentary integrates historical and modern findings that underpin our understanding of the cell-specific functions of the Tribbles (TRIB) proteins that bear on tumorigenesis. We touch on the initial discovery of roles played by mammalian TRIB proteins in a diverse range of cell-types and pathologies, for example, TRIB1 in regulatory T-cells, TRIB2 in acute myeloid leukaemia and TRIB3 in gliomas; the origins and diversity of TRIB1 transcripts; microRNA-mediated (miRNA) regulation of TRIB1 transcript decay and translation; the substantial conformational changes that ensue on binding of TRIB1 to the transcription factor C/EBPα; and the unique pocket formed by TRIB1 to sequester its C-terminal motif bearing a binding site for the E3 ubiquitin ligase COP1. Unashamedly, the narrative is relayed through the perspective of the Tribbles Research and Innovation Network, and its establishment, progress and future ambitions: the growth of TRIB and COP1 research to hasten discovery of their cell-specific contributions to health and obesity-related cancers.

SUBMITTER: Ruiz-Cantos M

PROVIDER: S-EPMC8467127 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Musings from the Tribbles Research and Innovation Network.

Ruiz-Cantos Miriam M Hutchison Claire E CE Shoulders Carol C CC

Cancers 20210908 18

This commentary integrates historical and modern findings that underpin our understanding of the cell-specific functions of the Tribbles (TRIB) proteins that bear on tumorigenesis. We touch on the initial discovery of roles played by mammalian TRIB proteins in a diverse range of cell-types and pathologies, for example, TRIB1 in regulatory T-cells, TRIB2 in acute myeloid leukaemia and TRIB3 in gliomas; the origins and diversity of <i>TRIB1</i> transcripts; microRNA-mediated (miRNA) regulation of ...[more]

PMID: 34572744

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Dataset Information

Musings from the Tribbles Research and Innovation Network.

Publications

Musings from the Tribbles Research and Innovation Network.

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