Exploring the Bile Stress Response of Lactobacillus mucosae LM1 through Exoproteome Analysis.

ABSTRACT: Lactobacillus sp. have long been studied for their great potential in probiotic applications. Recently, proteomics analysis has become a useful tool for studies on potential lactobacilli probiotics. Specifically, proteomics has helped determine and describe the physiological changes that lactic acid bacteria undergo in specific conditions, especially in the host gut. In particular, the extracellular proteome, or exoproteome, of lactobacilli contains proteins specific to host- or environment-microbe interactions. Using gel-free, label-free ultra-high performance liquid chromatography tandem mass spectrometry, we explored the exoproteome of the probiotic candidate Lactobacillus mucosae LM1 subjected to bile treatment, to determine the proteins it may use against bile stress in

SUBMITTER: Bagon BB 

PROVIDER: S-EPMC8467624 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature