Ontology highlight
ABSTRACT:
SUBMITTER: Abdullah O
PROVIDER: S-EPMC8469531 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20210918 18
Aurora-A kinase, a key mitosis regulator, is expressed in a cell cycle-dependent manner and has an essential role in maintaining chromosomal stability and the normal progression of the cell through mitosis. Aurora-A kinase is overexpressed in many malignant solid tumors, such as breast, ovarian, colon, and pancreatic cancers. Thus, inhibiting Aurora-A kinase activity is a promising approach for cancer treatment. Here, new triazole derivatives were designed as bioisosteric analogues of the known ...[more]