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Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla.

ABSTRACT: Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A-O (2-16), and a C-6-C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids were obtained by chiral HPLC separation and their absolute configurations were determined by electronic circular dichroism (ECD) data analysis.

SUBMITTER: Ma X

PROVIDER: S-EPMC8469674 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla.

Ma Xiaoli X Chen Hongwei H Zhu Sisi S Tu Pengfei P Jiang Yong Y

Molecules (Basel, Switzerland) 20210920 18

Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (±)-microphyltrine A (1), 15 dimeric carbazole racemates, (±)-microphyldines A-O (2-16), and a C-6-C-3″-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of th ...[more]

PMID: 34577160

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