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Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact.

ABSTRACT: The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of Ligilactobacillus salivarius MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product (L. salivarius MP101: 9.3 log₁₀ CFU per unit) for 4 months. Nasal and fecal samples were analyzed for 37 immune factors at recruitment and at the end of the study. After the trial, no change in the GDS/FAST scores were found but, in contrast, the values for the Barthel index and the MNA score improved significantly. The concentrations of some immune factors changed significantly after the trial, including a decrease in the concentrations of BAFF/TNFSF13B, APRIL/TNFSF13, IL8, IL31, osteopontin, sTNF-R1, and sTNF-R2, and an increase in chitinase 3-like 1, IL19, IL35, and pentraxin 3 was also observed. In conclusion, L. salivarius MP101 seems to be a promising strain for improving or maintaining health in this highly vulnerable population.

SUBMITTER: Mozota M

PROVIDER: S-EPMC8470390 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Simple Summary Antibiotic usage in swine husbandry contributes to the emergence and dissemination of antibiotic-resistant bacteria, posing a serious threat to public health. Consequently, alternative strategies are required to mitigate this issue. In a previous study, we showed that the replacement of metaphylactic antimicrobials with an administration of Ligilactobacillus salivarius MP100 for two years to sows and piglets changed the fecal microbiota and short-chain fatty acid profiles in an intensive pig farm. In this work, we compared the productivity-related data between a 2-year period of routine metaphylactic antibiotherapy and the first 2 years in which such a practice was replaced by the probiotic strain. Subsequently, the composition of the meat of the animals ingesting the probiotic strain was compared to that of animals with a similar diet but receiving metaphylactic antibiotherapy. This probiotic intake did not negatively alter the composition of the meat and was associated with an increase in the concentration of inosine and a slight tendency for increasing the thickness of the subcutaneour lumbar fat and intramuscular fat content. These factors are considered as biomarkers of meat quality and health. Therefore, the substitution of metaphylactic antimicrobials with a daily administration of the probiotic strain was associated with beneficial productivity and quality outcomes. Abstract The metaphylactic use of antimicrobials in swine farms contributes to the emergence of antibiotic-resistant bacteria, which constitutes a major challenge for public health. Alternative strategies are required to eradicate their routine use. In a previous study, metaphylactic antimicrobials were replaced by the administration of Ligilactobacillus salivarius MP100 to sows and piglets for two years. This practice positively modified the fecal microbiota and metabolic profiles in the farm. In this work, the farm dataset was used to compare the productivity-related parameters between a 2-year period of routine metaphylactic antibiotherapy and the first 2 years of a replacement with the probiotic strain. The probiotic period improved these productivity-related parameters, from litter size to growth performance. In addition, samples of Longissimus lumborum, including skin and subcutaneous fat, were obtained from the animals ingesting the probiotic strain and controls (metaphylactic antibiotherapy) and analyzed for their pH, water holding capacity, composition, and metabolic profiling. The probiotic intake did not negatively affect the meat composition and was associated with an increase in inosine concentration and a slight tendency for increasing the intramuscular fat content. These factors are considered as biomarkers of meat quality. In conclusion, the substitution of metaphylactic antimicrobials with the administration of the probiotic strain was associated with beneficial productivity and meat quality outcomes.

Dataset Information

Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact.

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