Browse
Submit Data
Databases
API
Help

Dataset Information

41 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Highly Sensitive Detection for Mercury Ions Using Graphene Oxide (GO) Sensors.

ABSTRACT: The mercury ion (Hg²⁺) is one of the heavy metal ions, and its presence in trace amounts can cause physiological damage to an organism. Traditional methods of Hg²⁺ detection have been useful but have also had numerous limitations and challenges, and as a result, it is important to design new and sophisticated methods that can aid in the detection of Hg²⁺. In this paper, two fluorescent dyes, carboxyfluorescein (FAM) and SYBR Green I, were used to label and intercalate DNA probes immobilized on the surface of graphene oxide (GO) for sensors to detect Hg²⁺. FAM and SYBR Green I dye share close excitation and emission wavelength spectra, which can promote and amplify the detection of signals, and also increase the limit of detection (LOD). The results showed that the limit of detection in this method was 0.53 nM. Moreover, when the sensors with double amino groups on the surface of GO were carried out to detect Hg²⁺, a limit of detection was improved to 0.43 nM. The sensors were then applied in the real sample. The results show that this method has a promising potential in Hg²⁺ detection.

SUBMITTER: Liu L

PROVIDER: S-EPMC8470607 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Highly Sensitive Ratiometric Fluorescent Paper Sensors for the Detection of Fluoride Ions.

Project description:Two sensitive and ratiometric fluorescent probes (probe I and probe II) were developed for the detection of fluoride ions. Probe I can detect fluoride ions quantitatively within a range of 0-6 μM and a detection limit of 73 nM, while probe II has a range of 0-40 μM and a detection limit of 138 nM. The test strips from probe I are quickly able to recognize F- (5 min) inside of the F- safety level in drinking water (1.0 mg/L, ∼5 μM) under 254 nm ultraviolet light, and the test strips from probe II quickly recognize F- (12 min) in dangerously high F- levels in water (4.0 mg/L, ∼21 μM) under 254 nm ultraviolet light. This combination of fluorescent paper sensors from probe I and probe II can be used as a simple and convenient tool to determine whether water is safe to drink or dangerous.

| S-EPMC6648022 | biostudies-literature

Graphene-Oxide-Based Electrochemical Sensors for the Sensitive Detection of Pharmaceutical Drug Naproxen.

Project description:Here we report on a selective and sensitive graphene-oxide-based electrochemical sensor for the detection of naproxen. The effects of doping and oxygen content of various graphene oxide (GO)-based nanomaterials on their respective electrochemical behaviors were investigated and rationalized. The synthesized GO and GO-based nanomaterials were characterized using a field-emission scanning electron microscope, while the associated amounts of the dopant heteroatoms and oxygen were quantified using x-ray photoelectron spectroscopy. The electrochemical behaviors of the GO, fluorine-doped graphene oxide (F-GO), boron-doped partially reduced graphene oxide (B-rGO), nitrogen-doped partially reduced graphene oxide (N-rGO), and thermally reduced graphene oxide (TrGO) were studied and compared via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). It was found that GO exhibited the highest signal for the electrochemical detection of naproxen when compared with the other GO-based nanomaterials explored in the present study. This was primarily due to the presence of the additional oxygen content in the GO, which facilitated the catalytic oxidation of naproxen. The GO-based electrochemical sensor exhibited a wide linear range (10 mM-1 mM), a high sensitivity (0.60 µAµM-1cm-2), high selectivity and a strong anti-interference capacity over potential interfering species that may exist in a biological system for the detection of naproxen. In addition, the proposed GO-based electrochemical sensor was tested using actual pharmaceutical naproxen tablets without pretreatments, further demonstrating excellent sensitivity and selectivity. Moreover, this study provided insights into the participatory catalytic roles of the oxygen functional groups of the GO-based nanomaterials toward the electrochemical oxidation and sensing of naproxen.

| S-EPMC7085571 | biostudies-literature

Highly Sensitive Simultaneous Detection of Mercury and Copper Ions by Ultrasmall Fluorescent DNA-Ag Nanoclusters.

Project description:Fluorescent metal nanoclusters (NCs) have given rise to a new class of fluorescent nanomaterials for the detection of heavy metals. Here, we design a simple, rapid and highly sensitive sensing nanosystem for the detection of Hg2+ and Cu2+ based on fluorescence quenching of ultrasmall DNA-Ag NCs. The fluorescence intensity of DNA-Ag NCs was selectively quenched by Hg2+ and Cu2+, and the limit of detection (LOD) was found to be 5 nM and 10 nM, respectively. The technique was renewable employment by EDTA addition and successfully applied to detection of Hg2+ and Cu2+ in domestic water samples. The quantum yield (QY) of DNA-Ag NCs was significantly higher to ~30% compared to traditional water-soluble fluorescent metal NCs. The DNA-Ag NC detection system make it potentially suitable for detecting Hg2+ and Cu2+ and monitoring water quality in a wide range of samples regulated under the Environmental Protection Agency.

| S-EPMC4019454 | biostudies-literature

Ratiometric Fluorescent Nanoprobe for Highly Sensitive Determination of Mercury Ions.

Project description:In this study, a novel dual-emission ratiometric fluorescent nanoprobe (RFN) was synthesized and ultilized for highly sensitive determination of mercury ions. In this nanoprobe, fluorescein isothiocyanate (FITC) doped silica (SiO2) served as a reference signal, FITC-SiO2 microspheres were synthesized and modified with amino groups, and then Au Nanoclusters (AuNCs) were combined with the amino groups on the surface of the FITC-SiO2 microspheres to obtain the RFN. The selectivity, stability, and pH of the RFN were then optimized, and the determination of mercury ions was performed under optimal conditions. The probe fluorescence intensity ratio (F520 nm/F680 nm) and Hg2+ concentration (1.0 × 10-10 mol/L to 1.0 × 10-8 mol/L) showed a good linear relationship, with a correlation coefficient of R2 = 0.98802 and a detection limit of 1.0 × 10-10 mol/L, respectively. The probe was used for the determination of trace mercury ion in water samples, and the recovery rate was 98.15~100.45%, suggesting a wide range of applications in monitoring pollutants, such as heavy metal ion and in the area of environmental protection.

| S-EPMC6631757 | biostudies-literature

Wearable, stable, highly sensitive hydrogel-graphene strain sensors.

Project description:A stable and highly sensitive graphene/hydrogel strain sensor is designed by introducing glycerol as a co-solvent in the formation of a hydrogel substrate and then casting a graphene solution onto the hydrogel in a simple, two-step method. This hydrogel-based strain sensor can effectively retain water in the polymer network due to the formation of strong hydrogen bonding between glycerol and water. The addition of glycerol not only enhances the stability of the hydrogel over a wider temperature range, but also increases the stretchability of the hydrogel from 800% to 2000%. The enhanced sensitivity can be attributed to the graphene film, whereby the graphene flakes redistribute to optimize the contact area under different strains. The careful design enables this sensor to be used in both stretching and bending modes. As a demonstration, the as-prepared strain sensor was applied to sense the movement of finger knuckles. Given the outstanding performance of this wearable sensor, together with the proposed scalable fabrication method, this stable and sensitive hydrogel strain sensor is considered to have great potential in the field of wearable sensors.

| S-EPMC6404424 | biostudies-literature

Label-Free, Highly Sensitive Electrochemical Aptasensors Using Polymer-Modified Reduced Graphene Oxide for Cardiac Biomarker Detection.

Project description:Acute myocardial infarction (AMI), also recognized as a "heart attack," is one leading cause of death globally, and cardiac myoglobin (cMb), an important cardiac biomarker, is used for the early assessment of AMI. This paper presents an ultrasensitive, label-free electrochemical aptamer-based sensor (aptasensor) for cMb detection using polyethylenimine (PEI)-functionalized reduced graphene oxide (PEI-rGO) thin films. PEI, a cationic polymer, was used as a reducing agent for graphene oxide (GO), providing highly positive charges on the rGO surface and allowing direct immobilization of negatively charged single-strand DNA aptamers against cMb via electrostatic interaction without any linker or coupling chemistry. The presence of cMb was detected on Mb aptamer-modified electrodes using differential pulse voltammetry via measuring the current change due to the direct electron transfer between the electrodes and cMb proteins (Fe3+/Fe2+). The limits of detection were 0.97 pg mL-1 (phosphate-buffered saline) and 2.1 pg mL-1 (10-fold-diluted human serum), with a linear behavior with logarithmic cMb concentration. The specificity and reproducibility of the aptasensors were also examined. This electrochemical aptasensor using polymer-modified rGO shows potential for the early assessment of cMb in point-of-care testing applications.

| S-EPMC7057319 | biostudies-literature

Highly Sensitive Electrochemical Biosensor Using Folic Acid-Modified Reduced Graphene Oxide for the Detection of Cancer Biomarker.

Project description:The detection of cancer biomarkers in the early stages could prevent cancer-related deaths significantly. Nanomaterials combined with biomolecules are extensively used in drug delivery, imaging, and sensing applications by targeting the overexpressed cancer proteins such as folate receptors (FRs) to control the disease by providing earlier treatments. In this investigation, biocompatible reduced graphene oxide (rGO) nanosheets combined with folic acid (FA)-a vitamin with high bioaffinity to FRs-is utilized to develop an electrochemical sensor for cancer detection. To mimic the cancer cell environment, FR-β protein is used to evaluate the response of the rGO-FA sensor. The formation of the rGO-FA nanocomposite was confirmed through various characterization techniques. A glassy carbon (GC) electrode was then modified with the obtained rGO-FA and analyzed via differential pulse voltammetry (DPV) for its specific detection towards FRs. Using the DPV technique, the rGO-FA-modified electrode exhibited a limit of detection (LOD) of 1.69 pM, determined in a linear concentration range from 6 to 100 pM. This excellent electrochemical performance towards FRs detection could provide a significant contribution towards future cancer diagnosis. Moreover, the rGO-FA sensing platform also showed excellent specificity and reliability when tested against similar interfering biomolecules. This rGO-FA sensor offers a great promise to the future medical industry through its highly sensitive detection towards FRs in a fast, reliable, and economical way.

| S-EPMC8150695 | biostudies-literature

Stretchable and highly sensitive graphene-on-polymer strain sensors.

Project description:The use of nanomaterials for strain sensors has attracted attention due to their unique electromechanical properties. However, nanomaterials have yet to overcome many technological obstacles and thus are not yet the preferred material for strain sensors. In this work, we investigated graphene woven fabrics (GWFs) for strain sensing. Different than graphene films, GWFs undergo significant changes in their polycrystalline structures along with high-density crack formation and propagation mechanically deformed. The electrical resistance of GWFs increases exponentially with tensile strain with gauge factors of ~10(3) under 2~6% strains and ~10(6) under higher strains that are the highest thus far reported, due to its woven mesh configuration and fracture behavior, making it an ideal structure for sensing tensile deformation by changes in strain. The main mechanism is investigated, resulting in a theoretical model that predicts very well the observed behavior.

| S-EPMC3499758 | biostudies-literature

Highly Sensitive Hall Sensors Based on Chemical Vapor Deposition Graphene.

Project description:In this work, we demonstrate highly sensitive and scalable Hall sensors fabricated by adopting arrays of monolayer single-crystal chemical vapor deposition (CVD) graphene. The devices are based on graphene Hall bars with a carrier mobility of >12000 cm2 V-1 s-1 and a low residual carrier density of ∼1 × 1011 cm-2, showing Hall sensitivity higher than 5000 V A-1 T-1, which is a value previously only achieved when using exfoliated graphene encapsulated with flakes of hexagonal boron nitride. We also implement a facile and scalable polymeric encapsulation, allowing the performance of graphene Hall bars to be stabilized when measured in an ambient environment. We demonstrate that this capping method can reduce the degradation of electrical transport properties when the graphene devices are kept in air over 10 weeks. State-of-the-art performance of the realized devices, based on scalable synthesis and encapsulation, contributes to the proliferation of graphene-based Hall sensors.

| S-EPMC11348313 | biostudies-literature

Reduced Graphene Oxide-Coated Si Nanowires for Highly Sensitive and Selective Detection of Indoor Formaldehyde.

Project description:Although significant developments have been made in the low-concentration formaldehyde monitoring in indoor air by using gas sensors, they still suffer from insufficient performance for achieving ppb-level detection. In this work, <100> oriented Si nanowires (SiNWs) with high specific surface area were prepared via metal-assisted chemical etching method (MACE), and then were uniformly coated with graphene oxide (GO) followed by the subsequent reductive process in H2/Ar atmosphere at 800 °C to obtain reduced graphene oxide (RGO). The RGO coating (RGO@n-SiNWs) obviously enhances SiNWs sensitivity to low-concentration formaldehyde, benefiting from the increased specific surface area, the sensitization effect of RGO, and the formation of p-n junction between SiNWs and RGO. Specifically, RGO@n-SiNWs exhibits a high response of 6.4 to 10 ppm formaldehyde at 300 °C, which is about 2.6 times higher than that of pristine SiNWs (~ 2.5). Furthermore, the RGO@n-SiNWs show a high response of 2.4 to 0.1 ppm formaldehyde which is the largest permissive concentration in indoor air, a low detection limit of 35 ppb obtained by non-linear fitting, and fast response/recovery times of 30 and 10 s. In the meanwhile, the sensor also shows high selectivity over other typical interfering gases such as ethanol, acetone, ammonia, methanol, xylene, and toluene, and shows a high stability over a measurement period of 6 days. These results enable the highly sensitive, selective, and stable detection of low-concentration formaldehyde to guarantee safety of indoor environment.

| S-EPMC6419648 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data