Ontology highlight
ABSTRACT:
SUBMITTER: Cluzeau T
PROVIDER: S-EPMC8471083 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Cluzeau Thomas T Loschi Michael M Fenaux Pierre P Komrokji Rami R Sallman David A DA
International journal of molecular sciences 20210918 18
Targeting TP53 mutated myelodysplastic syndromes and acute myeloid leukemia remains a significant unmet need. Recently, new drugs have attempted to improve the outcomes of this poor molecular subgroup. The aim of this article is to review all the current knowledge using active agents including hypomethylating agents with venetoclax, eprenetapopt or magrolimab. We include comprehensive analysis of clinical trials to date evaluating these drugs in TP53 myeloid neoplasms as well as discuss future n ...[more]