The Endocannabinoid System and Cannabidiol: Past, Present, and Prospective for Cardiovascular Diseases.

ABSTRACT: In the past, cannabis was commonly associated with mysticism and illegality. Fortunately, in recent years perspectives and discourses have changed. More prominence has been given to the rigorous scientific effort that led to the discovery of cannabis' many physiological actions and endogenous signalling mechanisms. The endocannabinoid system is a complex and heterogeneous pro-homeostatic network comprising different receptors with several endogenous ligands, numerous metabolic enzymes and regulatory proteins. Therefore, it is not surprising that alterations and dysfunctions of the endocannabinoid system are observed in almost every category of disease. Such high degree of pathophysiological involvement suggests the endocannabinoid system is a promising therapeutic target and prompted the t

SUBMITTER: Rabino M 

PROVIDER: S-EPMC8472406 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature