Elevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most aggressive type of human brain tumor with a poor prognosis and a low survival rate. Secreted proteins from tumors are recently considered as important modulators to promote tumorigenesis by communicating with microenvironments. Repulsive guidance molecule A (RGMA) was initially characterized as an axon guidance molecule after secretion in the brain during embryogenesis but has not been studied in GBM. In this study, we investigated secreted gene expression patterns and the correlation between RGMA expression and prognosis in GBM using in silico analysis.

Methods

RGMA mRNA levels in normal human astrocyte (NHA), human glioma cells, and GBM patient-derived glioma stem cells (GSCs) were assessed by qRT-PCR. Patient survival analy

SUBMITTER: Phan TL 

PROVIDER: S-EPMC8473061 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature