Ontology highlight
ABSTRACT:
SUBMITTER: Scott CAP
PROVIDER: S-EPMC8473161 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Scott Connor A P CAP Amarilla Alberto A AA Bibby Summa S Newton Natalee D ND Hall Roy A RA Hobson-Peters Jody J Muller David A DA Chappell Keith J KJ Young Paul R PR Modhiran Naphak N Watterson Daniel D
Viruses 20210915 9
The use of dengue virus (DENV) vaccines has been hindered by the complexities of antibody dependent enhancement (ADE). Current late-stage vaccine candidates utilize attenuated and chimeric DENVs that produce particles of varying maturities. Antibodies that are elicited by preferentially exposed epitopes on immature virions have been linked to increased ADE. We aimed to further understand the humoral immunity promoted by DENV particles of varying maturities in an AG129 mouse model using a chimeri ...[more]