Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders.

ABSTRACT: Pregnancy is a challenging physiological process that involves maternal adaptations to the increasing energetics demands imposed by the growing conceptus. Failure to adapt to these requirements may result in serious health complications for the mother and the baby. The mitochondria are biosynthetic and energy-producing organelles supporting the augmented energetic demands of pregnancy. Evidence suggests that placental mitochondria display a dynamic phenotype through gestation. At early stages of pregnancy placental mitochondria are mainly responsible for the generation of metabolic intermediates and reactive oxygen species (ROS), while at later stages of gestation, the placental mitochondria exhibit high rates of oxygen consumption. This review describes the metabolic fingerprint of the pl

SUBMITTER: Sanchez-Aranguren L 

PROVIDER: S-EPMC8473347 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature