Dataset Information

Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO₂ spectrum.

ABSTRACT:

Background & aims

Significantly worse survival has been reported in patients with hepatopulmonary syndrome (HPS) and partial pressure of arterial oxygen (PaO₂) <45 mmHg undergoing liver transplantation. Long-term pre- and post-transplant outcomes based on degree of hypoxaemia were re-examined.

Methods

A retrospective analysis of 1,152 HPS candidates listed with an approved HPS model for end-stage liver disease (MELD) exception was performed. A Fine and Gray competing risks model was utilised to evaluate pre-transplant outcomes for PaO₂ thresholds of <45, 45 to <60, and ≥60 mmHg. Post-transplant survival was analysed using the Kaplan-Meier method.

Results

Patients with a PaO₂ <45 mmHg were significantly more likely to undergo transplantation (hazard ratio [HR] 1.51; 95% CI 1.12-2.03), whereas patients with higher MELD scores had lower hazard of transplant (HR 0.80, 95% CI 0.67-0.95, p = 0.011) and higher hazard of pre-transplant death (HR 2.29, 95% CI 1.55-3.37, p <0.001). Post-transplantation, patients with a PaO₂ <45 mmHg had lower survival (p = 0.04) compared with patients with a PaO₂ ≥45 to <50 mmHg, with survival curves significantly different at 2.6 years (75% survival compared with 86%) and median survival of 11.5 and 14.1 years, respectively. Cardiac arrest was a more likely (p = 0.025) cause of death for these patients. Cardiac arrest incidence in patients who died with a PaO₂ >50 mmHg was 6.2%.

Conclusions

Patients with a PaO₂ <45 mmHg had a significantly higher rate of transplantation, and higher calculated MELD scores were associated with significantly higher pre-transplant mortality. Although post-transplant survival was lower in patients with a PaO₂ <45 mmHg, the median survival was 11.5 years, and survival curves only became significantly different at 2.6 years. This suggests that patients with HPS do benefit from transplantation up to 2-3 years post-transplant regardless of the severity of pre-transplant hypoxaemia.

Lay summary

A total of 1,152 patients with hepatopulmonary syndrome listed for liver transplant were analysed. Patients with a low PaO₂ <45 mmHg had a high likelihood of transplantation. If associated with advanced liver disease, the mortality risk was higher for patients with hepatopulmonary syndrome on the wait list. After liver transplantation, patients with a PaO₂ <45 mmHg had a lower survival, but this only became significant after 2.6 years, and the median survival was 11.5 years. This suggests that patients with hepatopulmonary syndrome do benefit from transplantation.

SUBMITTER: Kadry Z

PROVIDER: S-EPMC8473556 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Background & aimsPatients with hepatopulmonary syndrome (HPS) are prioritized for liver transplantation (given exception points) due to their high pre- and post-transplantation mortality. However, few studies have evaluated the outcomes of these patients.MethodsWe performed a retrospective cohort study using data submitted to the United Network for Organ Sharing in a study of the effects of room-air oxygenation on pre- and post-transplantation outcomes of patients with HPS. We identified thresholds associated with post-transplantation survival using cubic spline analysis and compared overall survival times of patients with and without HPS.ResultsFrom 2002 through 2012, nine hundred and seventy-three patients on the liver transplant waitlist received HPS exception points. There was no association between oxygenation and waitlist mortality among patients with HPS exception points. Transplant recipients with more severe hypoxemia had increased risk of death after liver transplantation. Rates of 3-year unadjusted post-transplantation survival were 84% for patients with PaO2 of 44.1-54.0 mm Hg vs 68% for those with PaO2 ≤ 44.0 mm Hg. In multivariable Cox models, transplant recipients with an initial room-air PaO2 ≤ 44.0 mm Hg had significant increases in post-transplantation mortality (hazard ratio = 1.58; 95% confidence interval [CI]: 1.15-2.18) compared with those with a PaO2 of 44.1-54.0 mm Hg. Overall mortality was significantly lower among waitlist candidates with HPS exception points than those without (hazard ratio = 0.82; 95% CI: 0.70-0.96), possibly because patients with HPS have a reduced risk of pre-transplantation mortality and similar rate of post-transplantation survival.ConclusionsAlthough there was no association between pre-transplantation oxygenation and waitlist survival in patients with HPS Model for End-Stage Liver Disease exception points, a pre-transplantation room-air PaO2 ≤ 44.0 mm Hg was associated with increased post-transplantation mortality. HPS Model for End-Stage Liver Disease exception patients had lower overall mortality compared with others awaiting liver transplantation, suggesting that the appropriateness of the HPS exception policy should be reassessed.

Project description:Pao2 is the gold standard to assess acute hypoxic respiratory failure, but it is only routinely available by intermittent spot checks, precluding any automatic continuous analysis for bedside tools.ObjectiveTo validate a continuous and noninvasive method to estimate hypoxemia severity for all Spo2 values.Derivation cohortAll patients who had an arterial blood gas and simultaneous continuous noninvasive monitoring from 2011 to 2019 at Boston Children's Hospital (Boston, MA) PICU.Validation cohortExternal cohort at Sainte-Justine Hospital PICU (Montreal, QC, Canada) from 2017 to 2020.Prediction modelWe estimated the Pao2 using three kinds of neural networks and an empirically optimized mathematical model derived from known physiologic equations.ResultsWe included 52,879 Pao2 (3,252 patients) in the derivation dataset and 12,047 Pao2 (926 patients) in the validation dataset. The mean function on the last minute before the arterial blood gas had the lowest bias (bias -0.1% validation cohort). A difference greater than or equal to 3% between pulse rate and electrical heart rate decreased the intraclass correlation coefficients (0.75 vs 0.44; p < 0.001) implying measurement noise. Our estimated Pao2 equation had the highest intraclass correlation coefficient (0.38; 95% CI, 0.36-0.39; validation cohort) and outperformed neural networks and existing equations. Using the estimated Pao2 to estimate the oxygenation index showed a significantly better hypoxemia classification (kappa) than oxygenation saturation index for both Spo2 less than or equal to 97% (0.79 vs 0.60; p < 0.001) and Spo2 greater than 97% (0.58 vs 0.52; p < 0.001).ConclusionThe estimated Pao2 using pulse rate and electrical heart rate Spo2 validation allows a continuous and noninvasive estimation of the oxygenation index that is valid for Spo2 less than or equal to 97% and for Spo2 greater than 97%. Display of continuous analysis of estimated Pao2 and estimated oxygenation index may provide decision support to assist with hypoxemia diagnosis and oxygen titration in critically ill patients.

Dataset Information

Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO₂ spectrum.

Background & aims

Methods

Results

Conclusions

Lay summary

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO2 spectrum.

Background & aims

Methods

Results

Conclusions

Lay summary

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO₂ spectrum.