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Transport accessibility and social demand: A case study of the Tibetan Plateau.

ABSTRACT: The equity of transport accessibility is a prerequisite for sustainable development targets, especially in the ecologically fragile area of the Tibetan Plateau (also known as the Qinghai-Tibet Plateau). The relationship between transportation supply and social demand has become a key element of socioeconomic development and environmental protection in agricultural and pastoral areas. Based on data from transportation networks, permanent populations and the economy, this study uses a network analysis model, the coefficient of variation and the Gini coefficient to construct an index of social demand in townships and analyse the equity of transport accessibility on the Tibetan Plateau between 1980 and 2017; the principle of geographic distribution and the spatial relationship between transport accessibility and social demand at the township scale are also discussed. This study finds the following: the development of transportation has improved accessibility on the Tibetan Plateau, creating a highly accessible region with important cities as the nodes and major traffic arteries as the axes; both the coefficient of variation of transport accessibility and the Gini coefficient have increased slightly; and the equity of transport accessibility among townships on the Tibetan Plateau has exhibited a downward trend. Further, the social demand index is doubling every ten years, the spatial distribution has regional characteristics, and a decrease in permanent populations is the main reason for declining social demand index scores among townships. Townships with the lowest and highest social demand index scores for transportation development enjoy greater transportation benefits; there is a significant spatial relationship between social demand and location conditions (potential accessibility); the aggregation of social demand and accessibility types follows specific geographical distribution principles; and the Mangya-Gongshan Line delineates the distribution characteristics of township clusters with low social demand and low accessibility.

SUBMITTER: Gao X

PROVIDER: S-EPMC8476033 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:PurposeThis study aimed to assess the relationship of serum uric acid with metabolic syndrome and its components in Tibetan adults on the Tibetan plateau.MethodsA total of 307 participants were enrolled in this study and biochemical parameters including serum uric acid, fasting plasma glucose, white blood cell, lymphocyte count, mononuclear cells, alanine aminotransferase, aspartate aminotransferase, creatinine, and lipid profile were analyzed using standard methods. The IDF criteria were applied to define metabolic syndrome. The association of serum uric acid with metabolic syndrome and its components was evaluated by multivariable logistic regression models.ResultsThe overall prevalence of metabolic syndrome was 17.3% (53/307) with 19.6% (31/158) in females and 14.8% (22/149) in male participants. The prevalence of hyperuricemia was 40.7% (125/307) with significant differences between the male (53.7%,80/149) and female (28.5%,45/158) groups. In regression analysis, we observed that the risk of MetS was higher in participants in the hyperuricemia group (adjusted OR, 4.01; 95% CI, 2.02~7.99) compared with those in the normouricemia group. After adjusting for all confounding factors, a 9% higher risk of MetS could be shown in participants with SUA increased per 10umol/L (adjusted OR, 1.09; 95% CI, 1.04~1.14). These relationships were not affected by sex or age (p >0.05). After adjusting for the confounding factors, hyperuricemia is positively associated with abdominal obesity (adjusted OR, 2.53; 95% CI, 1.41~4.53), elevated blood pressure (adjusted OR, 2.61; 95% CI, 1.37~4.97), and elevated triglycerides(adjusted OR, 2.47; 95% CI, 1.09~5.57).ConclusionsIn our study, hyperuricemia is significantly associated with the prevalence of metabolic syndrome and part of its components, and these relationships are not affected by sex or age. Given the high prevalence of MetS and hyperuricemia among Tibetan adults, more studies are required to explore the role of SUA in the pathogenesis of MetS.

Project description:To examine the chemical composition, potential sources of solutes, and water quality of Lancangjiang River, the concentrations of major ions (Ca2+, Mg2+, Na+, K+, HCO3-, SO42-, Cl- and NO3-) in 45 river water samples collected in July and August 2019 were determined. Ca2+ and HCO3- are the predominant ions in river water. The extremely low K+ and NO3- concentrations and the sparse population suggest that the anthropogenic inputs are limited. The Pearson correlation coefficients and the elemental ratios Ca2+/Na+ versus Mg2+/Na+, Ca2+/Na versus HCO3-/Na+, [Ca2+ + Mg2+]/[HCO3-] versus [SO42-]/[HCO3-] reveal the mixing processes of different sources; the chemical composition of the river water is controlled by the mixture of carbonate weathering, evaporite weathering and silicate weathering inputs. To quantify the contributions of atmospheric input and rock dissolution, the forward method is employed in this study, which is based on the mass balance equation. The calculation results suggest the carbonate weathering inputs and gypsum dissolution make up the majority of the riverine cations, while silicate weathering and halite dissolution constitutes a relatively small proportion, the contributions of the atmospheric input are limited. The fast dissolution rate of evaporite and carbonate minerals and their lithologic distributions should be the key factor. To evaluate the water quality for drinking and irrigation purposes, the drinking water quality guidelines and the calculated parameters were employed, including sodium adsorption ratio (SAR), soluble sodium percentage (Na%,) and residual sodium carbonate (RSC). The assessments indicate that the river waters in the middle-lower reaches are generally suitable for irrigation and drinking purpose, and will not lead to health and soil problems, such as soil compaction and salinization. While in the upper reaches, the dissolution of carbonate and gypsum minerals transport abundant ions into river water and the river waters are not appropriate to use directly. This result highlights that the water quality status can also be affected by natural weathering processes in the area without anthropogenic inputs, where the long-time monitoring of water quality is also necessary.

Project description:Triplophysa fishes are the primary component of the fish fauna on the Tibetan Plateau and are well adapted to the high-altitude environment. Despite the importance of Triplophysa fishes on the plateau, the genetic mechanisms of the adaptations of these fishes to this high-altitude environment remain poorly understood. In this study, we generated the transcriptome sequences for three Triplophysa fishes, that is, Triplophysa siluroides, Triplophysa scleroptera, and Triplophysa dalaica, and used these and the previously available transcriptome and genome sequences from fishes living at low altitudes to identify potential genetic mechanisms for the high-altitude adaptations in Triplophysa fishes. An analysis of 2,269 orthologous genes among cave fish (Astyanax mexicanus), zebrafish (Danio rerio), large-scale loach (Paramisgurnus dabryanus), and Triplophysa fishes revealed that each of the terminal branches of the Triplophysa fishes had a significantly higher ratio of nonsynonymous to synonymous substitutions than that of the branches of the fishes from low altitudes, which provided consistent evidence for genome-wide rapid evolution in the Triplophysa genus. Many of the GO (Gene Ontology) categories associated with energy metabolism and hypoxia response exhibited accelerated evolution in the Triplophysa fishes compared with the large-scale loach. The genes that exhibited signs of positive selection and rapid evolution in the Triplophysa fishes were also significantly enriched in energy metabolism and hypoxia response categories. Our analysis identified widespread Triplophysa-specific nonsynonymous mutations in the fast evolving genes and positively selected genes. Moreover, we detected significant evidence of positive selection in the HIF (hypoxia-inducible factor)-1A and HIF-2B genes in Triplophysa fishes and found that the Triplophysa-specific nonsynonymous mutations in the HIF-1A and HIF-2B genes were associated with functional changes. Overall, our study provides new insights into the adaptations and evolution of fishes in the high-altitude environment of the Tibetan Plateau and complements previous findings on the adaptations of mammals and birds to high altitudes.

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Transport accessibility and social demand: A case study of the Tibetan Plateau.

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