Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer.

ABSTRACT:

Background

Although Helicobacter pylori (Hp) as high risk factor for gastric cancer have been investigated from human trial, present data is inadequate to explain the effect of Hp on the changes of metabolic phenotype of gastric cancer in different stages.

Purpose

Herein, plasma of human superficial gastritis (Hp negative and positive), early gastric cancer and advanced gastric cancer analyzed by UPLC-HDMS metabolomics can not only reveal metabolic phenotype changes in patients with gastric cancer of different degrees (30 Hp negative, 30 Hp positive, 20 early gastric cancer patients, and 10 advanced gastric cancer patients), but also auxiliarily diagnose gastric cancer.

Results

Combined with multivariate statistical analysis, the results represented biomarkers

SUBMITTER: Wang YP 

PROVIDER: S-EPMC8477711 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature