Comparative analysis of allele variation using allele frequencies according to sample size in Korean population.

ABSTRACT:

Background

Allele frequency using short tandem repeats (STRs) is used to calculate likelihood ratio for database match, to interpret DNA mixture and to estimate ethnic groups in forensic genetics. In Korea, three population studies for 23 STR loci have been conducted with different sample size for forensic purposes.

Objective

We performed comparative analysis to determine how the difference of sample size affects the allele frequency and allele variation within same ethnic population (i.e. Korean). Furthermore, this study was conducted to check how the sampling group and multiplex kit also affect allele variation such as rare alleles and population specific alleles.

Methods

To compare allele variation, we used allele frequencies of three population data published from

SUBMITTER: Park HC 

PROVIDER: S-EPMC8478755 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature