Long-term exhaustion of the inbreeding load in Drosophila melanogaster.

ABSTRACT: Inbreeding depression, the decline in fitness of inbred individuals, is a ubiquitous phenomenon of great relevance in evolutionary biology and in the fields of animal and plant breeding and conservation. Inbreeding depression is due to the expression of recessive deleterious alleles that are concealed in heterozygous state in noninbred individuals, the so-called inbreeding load. Genetic purging reduces inbreeding depression by removing these alleles when expressed in homozygosis due to inbreeding. It is generally thought that fast inbreeding (such as that generated by full-sib mating lines) removes only highly deleterious recessive alleles, while slow inbreeding can also remove mildly deleterious ones. However, a question remains regarding which proportion of the inbreeding load can be rem

SUBMITTER: Perez-Pereira N 

PROVIDER: S-EPMC8478893 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature