Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells.
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ABSTRACT: Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and deployed on these platforms an affinity-attenuated variant of interleukin-2, which selectively expands oligoclonal and polyfunctional AgS T cells in vitro and synergizes with CD80 signals for superior proliferation versus peptide stimulation.
SUBMITTER: Seidel RD
PROVIDER: S-EPMC8479091 | biostudies-literature |
REPOSITORIES: biostudies-literature
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